::::: Malaysian Society Biochemistry & Molecular Biology ::::::

Call for Papers
--------------------------------------------------------------------------------------------

The organising committee welcomes the submission of original contributions for oral and poster presentation. Each participant is limited to ONE paper only but may co-author other papers. Abstracts should be single spaced, in Times New Roman font size 12 and not exceeding 250 words.

Abstracts for oral and poster presentations should be submitted by 1st June 2012 using the Abstract Submission Form provided below.

Abstracts will only be accepted for presentation upon receipt of the registration form AND registration fee payment by 17th June 2012.

Download Abstract Submission [ Form ]

Abstracts should be submitted to: abstracts37@msbmb.org

-------------------------------------------------------------------------------------------

NEW INDUCIBLE NITRIC OXIDE SYNTHASE AND TYROSINASE INHIBITORS FROM DIARYLPENTANOIDS DERIVATIVES

¹, FARIDA HARYANI AB. AZIZ¹, SYAHIDA AHMAD¹,²,
KHOZIRAH SHAARI²,³, FARIDAH ABAS²,⁴, DAUD AHMAD ISRAF ALI ²,⁵
AND MOHD. NORDIN HAJI LAJIS²,³

¹Faculty of Biotechnology and Biomolecular Sciences,²Institute of Biosciences,³Faculty
of Sciences, ⁴Faculty of Food Science and Technology, ⁵Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor

In recent years, a number of projects have been carried out in developing synthesized bioactive compounds from naturally occurring substances as chemopreventive and anti-inflammatory agents. Therefore, a series of diarylpentanoids analogs were synthesized to evaluate their antioxidant, anti-inflammatory and anti-tyrosinase properties. Free radical scavenging activity (DPPH) method was used to determine the antioxidant activity of these analogs. Nitric oxide (NO) inhibitory activity in lipopolysaccharide (LPS, 1 μg/ml) and interferon-γ (IFN-γ, 100U/ml)-treated RAW 264.7 macrophages, were measured by using Griess assay. ………….